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Along with indicate + variance expression filtering, we moreover tried to cut back transcriptomic information utilizing solely genes reported inside the COSMIC Cancer Gene Consensus, genes current inside the RPPA dataset, random genes, or signature genes in key cellular pathways as reported by SPEED ( Parikh et al, 2010 ), notably, H202 (60 signature genes), IL-1 (141), JAK-STAT (114), MAPK